心理资本干预对广泛性焦虑障碍患者心理状况及其免疫功能的影响

Effects of psychological capital intervention on psychological status and immune function in patients with generalized anxiety disorder

目的探讨结合心理资本的综合性干预对广泛性焦虑障碍患者心理状况及其免疫功能的影响,促进患者心身康复。方法运用一般情况调查表、汉密尔顿焦虑量表(HAMA)、积极心理资本问卷(PPQ)对60例广泛性焦虑症患者心理健康状况进行调查,运用流式细胞术检测患者免疫功能。结果 (1)对照组患者心理资本的乐观维度在干预前后差异无统计学意义,HAMA及心理资本问卷的各维度及总分上,干预组和对照组在干预前后差异都具有统计学意义(P<0.01);(2)干预组患者焦虑情绪(P<0.05)及心理资本(P<0.01)在干预后改善程度均显著大于对照组患者;(3)干预组干预前后CD3^+、CD4^+、CD8^+上差异具有统计学意义(P<0.05),对照组仅在CD3^+上具有统计学意义(P<0.05)。结论广泛性焦虑障碍患者心理健康状况及免疫功能严重受损,采用融合心理资本的综合性心理干预可有效改善患者心理健康状况,其免疫功能抑制状况有所改善。

Objective To investigate the effects of comprehensive intervention of psychological capital on the psychological status and immune function of patients with generalized anxiety disorder, and to promote the rehabilita-tion of patients. Methods The mental health status of 60 patients with generalized anxiety disorder was investigated by using the general questionnaire, Hamilton anxiety scale （HAMA） and positive psychological capital questionnaire （PPQ）. The immune function was determined by flow cytometry. Results ①There was no significant difference on the optimism dimension of psychological capital in the control group before and after the intervention, whereas there were statistically significant differences in the dimensions and total scores of HAMA and PPQ between the intervention group and the control group before and after the intervation （P〈0.05）. ②The improvement of anxiety （P〈0.05） and psychological capital （P〈0.01） in the intervention group were significantly higher than those in the control group. ③There were statistically significant differences on the CD3^＋, CD4^＋and CD8^＋in the intervention group before and after the intervation （P〈0.05）, whereas there was statistically significant difference on the CD3^＋in the control group （P〈0.05）. Conclusion The mental health status and immune function of patients with generalized anxiety disorder are seriously impaired. The comprehensive intervention of psychological capital can improve the patients＇ mental health and inhibition of immune function.