头孢替坦异构体研究

Study on the epimers of cefotetan

目的研究头孢替坦的两个差向异构体d-头孢替坦和l-头孢替坦的转换规律,明确异构体间的转化条件。方法采用酸、碱、热、氧化、强光条件对头孢替坦进行破坏试验。结果在酸、碱、热条件下d-头孢替坦会向l-头孢替坦转化。结论本研究为头孢替坦及头孢替坦二钠合成过程中的反应条件提供依据,也给生产过程控制提供支持。

Objective To study the conversion rule of two epimers of cefotetan, d-cefotetan and l-cefotetan, and determine the transformation conditions between two epimers. Methods We had done the destruction tests （ including acid, alkali, heat, oxidation and light ） to cefotetan. Results Test results shew that d-cefotetan could convert to l-cefotetan in acid, alkali and heat. Conclusion The study provides the basis for the reaction conditions in the synthesis of cefotetan and cefotetan disodium, and it also provides support for the production process control.