安博诺治疗原发性高血压对降低心血管事件发生率的影响

Influence of COAP ROVEL in treatment of essential hypertension on reducing incidence of cardiovascular events

目的安博诺治疗原发性高血压对降低心血管事件发生率的影响。方法选取2013年1月~2016年1月原发性高血压120例,以随机分组方式,分为观察组和对照组,每组各60例,观察组给予安博诺+饮食治疗,对照组给予安慰剂+饮食治疗,收集两组治疗前后各项观察指标,并组间前后比较。结果给药前,观察组和对照组收缩压(SBP)、舒张压(DBP)基本相同,差异无统计学意义(P>0.05),观察组和对照组超敏C反应蛋白(Hs-CRP)、血浆一氧化氮(NO)、内皮素(ET-1)、(可溶性细胞间粘附分子-1)s ICAM-1、血管性血友病因子(vWF)基本相同,差异无统计学意义(P>0.05);给药84d,观察组SBP、DBP均显著低于对照组,差异有统计学意义(P<0.05),观察组Hs-CRP、ET-1、sICAM-1、vWF均显著低于对照组,差异有统计学意义(P<0.05),观察组NO显著高于对照组,差异有统计学意义(P<0.05);观察组心血管事件发生率显著低于对照组,差异有统计学意义(P<0.05)。结论安博诺通过降压及改善血管内皮功能,可降低原发性高血压心血管事件发生率,值得临床推广应用。

Objective To explore the influence of （Irbesartan and Hydrochlorothiazide tablets） COAP ROVEL in treatment of essential hypertension on reducing incidence of cardiovascular events. Methods 120 patients with essential hypertension who were admitted to our hospital from January 2013 to January 2016 were selected and they were divided into the observation group and the control group according to the random distribution,with 60 in each. The observation group was given COAP ROYEL and diet therapy while the control group was given placebo and diet therapy.Every observation index before and after treatment of two groups was collected and those of two groups were compared. Results Before medication, systolic blood pressure （SMP） and diastolic blood pressure （DBP） of the observation group and the control group were basically same and the difference was of no statistical Significance （P 〉 0.05）.In addition,high-sensitivity C-reactive protein （hs-CRP）,plasma nitric oxide （NO）,endothelin （ET-1）,soluble inter cellular adhesion molecule-1 （slCAM-1） and yon Willebrand factor （vWF） of the observation group and the control group was basically the same,and the difference was of no statistical significance （P 〉 O.05）.On 84 days of medication,SBP and DBP of the observation group were significantly lower than those of control group and differences were statistical significant （P 〈 0.05）.Hs-CRP,ET-1,sICAM-1 and vWF of the observation group were significantly lower than those of the control group and differences were statistical significant （P 〈 0.05）.NO of the observation group was significantly higher than that of the control group and the difference was statistical significant （P 〈 0.05）. The incidence of cardiovascular events of the observation group was significantly lower than that of the control group and the difference was statistical significant （P 〈 0.05）. Conclusion COAP ROVEL can reduce the incidence of cardiovascular events in primary essential hypertension by reducing blood press and improving vascular endothelial function, which is worthy of clinical promotion and application.