不同程度突发性聋患者血清心钠素水平与疗效的关系

Relationships between different level of serum artial natriuretic peptide of sudden hearing loss patients and the curative effect

目的检测突发性聋患者血清心钠素水平,初步探讨血清心钠素水平与突发性聋程度及疗效的关系。方法采用酶联免疫吸附试验(ELISA)方法检测77例突发性聋患者治血清心钠素水平。结果与正常对照组比较,突发性聋患者ANP含量显著升高(P<0.01),治疗有效组血清ANP含量在治疗后明显下降(P<0.01),而治疗无效组血清ANP含量虽有下降,但治疗前后ANP含量差异无统计意义(P>0.05)。结论心钠素可能参与突发性聋的病理生理过程。

Objective To detect the level of the serum atrial natriuretic peptide（ANP） in patients with sudden hearing loss（SHL）, and to study the relationships of the ANP degree and effect of SHL. Methods The level of serum ANP in 77 cases of SHL was detected br via enzyme-linked immunosorbent assay（ELISA）. Results The level of serum ANP in SHL group was higher than that in control group（P 〈 0.01）. The level of serum ANP in effective SHL group decreased signifieantly（P 〈 0.01）. Though the level of serum ANP in effectless SHL group decreased, the differences had no statistical significance（P 〉 0.05）. Conclusion ANP may play important role in the pathophysiology procedure of SHL.