糖尿病颅神经病变患者血清铁蛋白与25-（OH）维生素D3的变化

Changes of serum ferritin and 25- （ OH ） vitamin D3 in cranial neuropathy diabetic patients

目的观察血清铁蛋白与25-（OH）维生素D3在糖尿病颅神经病变患者中的变化。方法纳入单纯糖尿病患者50例，糖尿病颅神经病变患者46例，正常对照组40例，观察各组之间血清铁蛋白、25-（OH）维生素D3水平变化，分析两指标的相关性及其与糖尿病颅神经病变的相关性。结果单纯糖尿病组、糖尿病颅神经病变组血清铁蛋白高于正常对照组（P〈0．01），且糖尿病颅神经病变患者[（687．54±65．38）ng／m1]高于单纯糖尿病患者[（497．28±46．39）n∥ml，P〈0．01]；单纯糖尿病组、糖尿病颅神经病变组血清25-（OH）维生素D3低于正常对照组（P〈0．01），且糖尿病颅神经病变患者[（26．45±8．93）nmol／L]低于单纯糖尿病患者[（37．19±9．74）nmolfL，P〈0．01]；血清铁蛋白水平与25．（OH）维生素D3水平呈负相关（r=-0．59，／9〈0．01）。多因素非条件Logistic回归分析显示糖尿病颅神经病变与25-（OH）维生素D3呈负相关（P〈0．05）。结论血清铁蛋白水平的升高及25．（OH）维生素D3水平降低可能与糖尿病颅神经的发生发展有关。

Objective To observe the changes of serum ferritin and 25-（OH） vitamin D3 in pa- tients with diabetic cranial neuropathy. Methods There were 50 patients without diabetic Cranial neuropa- thy, 46 patients with diabetic cranial neuropathy, and 40 cases of normal control group. The changes of ser- um ferritin and 25-hydroxy vitamin D3 were observed in each group. The correlation between two indexes and the correlation with diabetic cranial neuropathy were analzyzed. Results The serum ferritin levels in diabetic group and diabetic neuropathy group were significantly higher than those in normal control group （ P 〈 0. 01 ）, and its level in patients with diabetic cranial neuropathy E （ 687.54 ± 65.38 ） ng/ml ] was sig- nificantly higher than that of patients without diabetic cranial neuropathy E （497.28 -＋ 46. 39 ） ng/ml, P 〈 0. 01 ]. The serum 25-（OH） vitamin D3 levels in the diabetic group and diabetic neuropathy group were lower than those in the control group （P 〈 O. 01 ）, and its level in patients with diabetic cranial neuropathy （26. 45 ＋ 8. 93 ） nmo]./1J was significantly less than that of patients without diabetic cranial neuropathy （37. 19 ＋ 9. 74 ）nmol/L,P 〈 0. 01 ]. Serum ferritin levels were positively correlated with 25- （ OH ） vita- min D3 （ r = - O. 59, P 〈 O. 01 ）. Multivariate unconditional Logistic regression analysis showed that diabet- ic neuropathy was negatively correlated with 25- （OH） vitamin D3 （ P 〈 0. 05 ）. Conclusions The increa- ses of serum ferritin and 25-（OH） vitamin D3 are closely related to the occurrence and development of dia- betic cranial neuropathy, which provides the theoretical basis for clinical intervention therapy.