不同方法治疗变应性鼻炎的疗效观察

Curative effect of allergic rhinitis treated by varied intervention

目的观察单一用药和联合用药对变应性鼻炎(AR)患者的治疗效果。方法选取120例中重度持续性AR患者,随机分为3组。A组单独用布地奈德,B组用布地奈德联合口服氯雷他定片,C组用布地奈德联合鼻腔局部生理盐水冲洗,分别对治疗前、治疗后4周、8周后患者鼻部症状评分(total nasal symptoms scores,TNSS)、体征评分和鼻结膜炎相关生活质量评分(rhinoconjunctivitis quality of life,RQLQ)进行评估。结果治疗4周、8周后,B、C组的TNSS评分、体征评分和RQLQ评分明显低于A组,差异有统计学意义(P<0.05),B、C组间比较差异无统计学意义(P>0.05)。结论对于中重度持续性AR患者,联合用药对减轻临床症状、提高生活质量有明显疗效,应根据患者具体情况采取个性化的治疗方法。

Objective To compare the effect of combined therapy and single therapy on moderate to severe persistent allergic rhinitis(AR). Methods 120 patients with moderate or severe persistent AR were randomly divided into group A(nasal budesonide),group B(nasal budesonide combinded with oral desloratadine) and group C(nasal budesonide combined with nasal saline irrigation). The total nasal symptoms scores(TNSS),clinical sign score and rhinoconjunctivitis quality of life(RQLQ) were evaluated before treatment,4 and 8 weeks after treatment. Results Compare with group A,the TNSS,clinical sign score and ROLQ 4 and 8 weeks after treatment of group B and group C were significantly lower,the difference was statistically significant(P<0.05). There were no significant differences between group B and group C(P>0.05). Conclusion For patients with moderate or severe persistent AR,combined medication can reduce clinical symptoms,improve the quality of life. Personalized treatment should be taken based on the specific situation of patients.