甲状腺功能减退对妊娠结局及产科并发症的影响

The pregnancy outcomes and complications of pregnancy with hypothyroidism

目的探讨妊娠期甲状腺功能减退对妊娠结局及并发症的影响。方法选择2014年1月~2015年6月来我院就诊的56例妊娠期甲状腺功能减退产妇作为研究组,收集同期来我院进行产检的正常产妇56例作为对照组。检测所有孕妇的促甲状腺激素（TSH）水平,检测时间为孕早期（3个月）、孕中期（6个月）、孕晚期（9个月）、产后1周;观察两组产妇的分娩结局及并发症发生情况。结果研究组在孕早期、孕中期、孕晚期、产后1周的TSH水平与对照组比较均明显升高,两组差异有统计学意义（P〈0.05）。研究组与对照组比较,剖宫产率、早产率、自发性流产率、围生儿病死率更高,产科并发症发生率更高,两组差异有统计学意义（P〈0.05）。结论妊娠期甲状腺功能减退产妇更容易出现不良妊娠结局,并发症发生率更高,应加强监测力度,早发现、早治疗,改善不良妊娠结局,降低并发症发生率。

Objective To investigate the pregnancy outcomes and complications of pregnancy with hypothyroidism. Methods Selected 56 cases of maternal hypothyroidism during pregnancy in our hospital from Jan 2014 to Jun2015 as study group,56 normal pregnant women who came to our hospital in the same period were selected as control group. TSH level at the early trimester,the middle trimestar,the later trimester and one week after delivery were detected.The outcomes and complications of two groups were compared. Results The levels of TSH in the early trimester,middle trimester,later trimester and one week after delivery were significantly higher than control group(P<0.05).The rate of cesarean section,premature delivery rate,spontaneous abortion rate,perinatal mortality rate and obstetric incidence of complications were significantly higher in study group than in control group(P<0.05). Conclusion Maternal hypothyroidism during pregnancy is more prone to cause adverse pregnancy outcomes,higher incidence of obstetric complications.We should strengthen monitoring,take early detection and early treatment to improve the adverse pregnancy outcomes and reduce the incidence of complications.