p28GANK在食管胃交界部癌中的表达研究

Expression of p28GANK in gastroesophageal junction cancer and its clinicopathological significance

目的探讨p28GANK在食管胃交界部(EGJ)癌中表达的临床意义。方法选取66例患者手术切除的EGJ癌及对应切缘癌旁组织标本,采用HE染色进行组织病理学观察,免疫组化染色检测p28GANK在EGJ癌及癌旁组织中的表达,对结果进行分析。结果鳞状细胞癌、腺癌分别占19.7%(13/66)、80.3%(53/66);肿瘤组织侵犯淋巴管或血管的占28.2%(19/66);肿瘤淋巴结转移的占45.5%(30/66)。p28GANK在鳞状细胞癌与腺癌中的阳性表达率比较差异无统计学意义(P>0.05);p28GANK在EGJ癌组织中的阳性表达率明显高于其在对应癌旁组织中的阳性表达率(P<0.05);p28GANK在EGJ癌中阳性表达与肿瘤淋巴结转移及较晚的TNM分期有关(P<0.05)。结论 p28GANK在EGJ癌中高表达,可能是EGJ癌重要的分子标志物。

Objective To investigate the expression of p28GANK in gastroesophageal junction（EGJ） cancer and its clinicopathological significance. Methods The expression of p28GANK was detected with immunohistochemical staining in 66 cases of EGJ cancer and corresponding normal tissue in the resection edge. The correlation of p28GANK expression with clinicopathological features was analyzed. Results Among 66 cases of EGJ cancer,13 were squamous cell carcinoma（19.7%） and 53 were denocarcinoma（80.3%）.Postoperative pathology showed that 28.2% patients（19/66） had lymphatic or vascular invasion; and 45.5%（30/66） had lymph node metastasis.There was no difference in p28GANK expression between squamous cell carcinoma and adenocarcinoma（P〈0.05）. P28 GANK expression was significantly stronger in cancer tissues than that in the corresponding non-cancerous tissue（P〈0.05）. The expression of p28GANK was correlated with lymph node metastasis and advanced TNM stage of EGJ cancer（P〈0.05）. Conclusion P28 GANK expression is upregulated in gastroesophageal junction cancer,indicating that it might be used as a tumor molecular marker for EGJ cancer.