低氧诱导因子与绝经后骨质疏松研究进展

Hypoxia inducible factor in postmenopausal osteoporosis:recent progress

低氧诱导因子(hypoxia inducible factor,HIF)在细胞对低氧的反应中起着至关重要的作用,参与葡萄糖代谢、血管重建和红细胞生成等多种病理生理过程。越来越多的研究表明HIF对骨生成、骨吸收及血管生成具有非常重要的作用,而骨血管结构和功能退变与绝经后骨质疏松的发生和发展存在着密切的联系。本文从HIF在骨生成、骨吸收、血管生成中的作用出发,综述了HIF与绝经后骨质疏松的关系及其在绝经后骨质疏松治疗中的应用前景。

Hypoxia inducible factor （HIF） plays a key role in the cellular response to hypoxia, and is involved in a variety of pathological and physiological processes such as glucose metabolism, vascular remodeling and erythropoiesis. Growing research suggests that HIF has an important effect on osteogenesis, bone resorption and angiogenesis; while the deterioration of bone vascular structures and functions is closely related to the development and progression of postmenopausal osteoporosis. In this review, we summarized the relationship between HIF and postmenopausal osteoporosis based on the roles of HIF in osteogenesis, bone resorption and angiogenesis, hoping to evaluate its therapeutic prospect on postmenopausal osteoporosis.