Cr-MIL-101-NH_2的手性后合成修饰

Chiral Postsynthetic Modification of Cr-MIL-101-NH_2

采用后合成修饰技术(postsynthetic modification,PSM)设计并合成手性金属-有机框架化合物(metal-organic frameworks,MOFs),将L型脯氨酸衍生物Boc-L-ProCl,后修饰到金属有机-框架化合物Cr-MIL-101-NH_2孔道中,制得手性金属有机-框架化合物Cr-MIL-101-PaB_2。经核磁(~1H NMR)结果证实,修饰产率高达64%,固体圆二色谱(CD)测试结果表明经后合成修饰后的CrMIL-101-PaB_2具有旋光性。红外光谱(IR)、氮气脱附-吸附、热重(TGA)、粉末X射线衍射(PXRD)手段对其进行表征。实验结果证实,为避免金属-有机框架化合物自组装的不确定性,采用后合成修饰技术,可按需合成手性金属有机-框架化合物。

By postsynthetic modification method （PSM）, chiral metal-organic frameworks （MOFs） were designed and synthesized. The L-proline derivative （Boc-L-ProC1） was anchored on the pore of Cr-MIL-101-NH2 by PSM method to gain a chiral MOFs （Cr-MIL-101-PaB2）. ~H NMR spectra confirmed the yield up to 64% by twice process of PSM, and solid circular dichroism （CD） result showed that Cr-MIL-101-PaB2was a chiral compound. Their structures were characterized by infrared spectroscopy （IR）, nitrogen desorption-adsorption, thermogravimetry （TGA）, powder X-ray diffraction （PXRD）. The experimental results confirmed that synthesized chiral MOFs by PSM method for the needed purpose can avoid the self-assembly uncertainty of MOFs.