摘要
制备了一个芳酰腙化合物4-氟-N′-(3-乙氧基-2-羟基苯亚甲基)苯甲酰肼(H2L)。利用H2L和VO(acac)2分别与甲基麦芽酚(mat)和乙基麦芽酚(Emat)在甲醇中反应,得到了2个配合物[VO(L)(mat)](1)和[VO(L)(Emat)](2)。通过元素分析、红外光谱、紫外可见光谱和核磁共振氢谱表征了这些化合物的结构。通过单晶X射线衍射进一步确定了化合物的结构。芳酰腙配体以二价阴离子的方式通过酚羟基氧、亚胺基氮和烯醇氧原子与钒原子进行配位。在每个配合物中,钒都采取八面体配位构型。将配合物通过灌胃对正常的大鼠和四氧嘧啶糖尿病大鼠给药2周时间,结果表明这两个配合物在剂量为10.0和20.0 mgV·kg-1时可以显著降低四氧嘧啶糖尿病大鼠的血糖值,而对于正常大鼠的血糖值却没有改变。
A new aroylhydrazone compound 4-fluoro-N'-(3-ethoxy-2-hydroxybenzylidene)benzohydrazide (H2L) was prepared. Reaction of H2L and VO(aeae)2 with maltol(mat) and ethylmaltol(Emat), respectively, in methanol afforded the complexes [VO(L)(mat)] (1) and [VO(L)(Emat)] (2). Both H2L and the oxovanadium complexes were characterized by elemental analysis, IR, UV-Vis and JH NMR spectra. The structures of the compounds were further confirmed by single crystal X-ray diffraction. The aroylhydrazone ligand, in its dianionic form, coordinated to the V atoms through the phenolate oxygen, imino nitrogen and enolate oxygen. The maltol and ethylmaltol ligands coordinated to the V atoms through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom in each complex is in oetahedral coordination. The complexes were administered intragastrically to both normal and alloxan-diabetic mice for two weeks. The biological activity results show that the complexes at doses of 10.0 and 20.0 mgv kg-l, can significantly decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2017年第5期905-912,共8页
Chinese Journal of Inorganic Chemistry
基金
辽宁省自然科学基金(No.2015020673)
辽宁师范大学开放实验室(No.cx20160102)资助项目
关键词
钒配合物
芳酰腙
晶体结构
类胰岛素活性
aroylhydrazone
oxovanadium(V) complex
crystal structure
insulin-like activity