三种抗病毒药物联用治疗妊娠合并艾滋病的效果

Effects of three antiviral drugs on the treatment of pregnancy with AIDS

目的探讨三种抗病毒药物联用治疗妊娠合并艾滋病的临床效果。方法选取2010年1月~2016年12月肇庆市端州辖区医院收治的妊娠合并艾滋病患者共120例,按照随机数字表法分为对照组和观察组,各60例。对照组使用齐多夫定片联合拉米夫定片进行母婴阻断治疗,观察组采用齐多夫定片、拉米夫定片联用奈韦拉平片进行母婴阻断治疗。统计两组患者的妊娠方式、胎儿存活情况、阻断效果以及不良反应的发生情况并进行比较。结果两组的分娩方式和胎儿存活情况比较,差异无统计学意义(P>0.05)。观察组阻断成功率(100.00%)显著高于对照组(91.67%)(P<0.05)。两组产妇的不良反应发生率和新生儿不良反应的总发生率比较,差异无统计学意义(P>0.05)。结论联合使用齐多夫定片、拉米夫定片、奈韦拉平片抗病毒药物可有效减少艾滋病母婴传播发生的概率,并且具有一定的安全性。

Objective To explore the clinical effect of three antiviral drugs in the treatment of pregnancy with AIDS. Methods A total of 120 cases of pregnant women with AIDS were selected from January 2010 to December 2016 in Duanzhou area hospital of Zhaoqing city,they were divided into control group and observation group according to the random number table,each group had 60 cases.The control group was treated with Zidovudine Tablets and Lamivudine Tablets.The observation group was treated with Zidovudine Tablets,Lamivudine Tablets and Nevirapine Tablets.Statisticsand analysis with pregnancy,fetal survival,blocking effect and the occurrence of adverse reactions of the two groupswere compared.Results In this study,the follow-up rate was 100%.There were no significant differences in the mode of delivery and fetal survival between the two groups （P〉0.05）.The success rate of the observation group （100.00%） was significantly higher than that of the control group （91.67%） （P〈0.05）.The total incidence of adverse reactions and the incidence of adverse events in the two groups had no significantly different （P〉0.05）.Conclusion The combination of Zidovudine Tablets,Lamivudine Tablets,Nevirapine Tablets can effectively reduce the probability of mother to child transmission of AIDS,and has a certain degree of safety.