老年非小细胞肺癌患者药物治疗研究进展

Research Progression on the Drug Therapy for Elderly Patients with Non-small Cell Lung Cancer

肺癌是目前世界上发病率最高的恶性肿瘤之一,然而,老年患者在临床研究中的代表性不足,导致缺乏指导治疗决定的证据。目前,辅助性化疗通常被推荐用于IB^III期非小细胞肺癌(NSCLC)手术切除术后治疗,老年晚期NSCLC患者的治疗方案则主要为单药化疗以及以铂类为基础的联合化疗。此外,靶向治疗及免疫靶向治疗成为新的研究方向。本文主要对辅助化疗及老年晚期NSCLC患者的药物治疗相关临床研究证据进展进行综述。

Lung cancer is one of the malignant tumors with high incidence. However, elderly patients are underrepresented in clinical studies, leading to a paucity of evidence to guide treatment decisions. At present, adjuvant chemotherapy is recommended for stage IB - III non-small cell lung cancer （NSCLC） after surgical resection. And the treatments for elderly patients with advanced NSCLC are mainly single-agent chemotherapy and platinum-based combination chemotherapy. Moreover, targeted therapy and immuno-targeted therapy have become new research directions. In this review, we summarized the progress of clinical research on adjuvant chemotherapy and medical treatment for elderly patients with advanced NSCLC.