梅州城区幽门螺杆菌感染与慢性荨麻疹的关系探讨

Relationship between Helicobacter Pylori Infection and Chronic Urticaria in Meizhou City

目的探究梅州城区幽门螺杆菌感染与慢性荨麻疹的关系。方法选取我院在2016年1月—2017年1月期间收治的常住或工作在梅州城区的慢性荨麻疹患者共90例,设为试验组,同期选取在我院进行健康检查者90例,设为正常组。将试验组中幽门螺杆菌阳性的患者随机分为对照组和观察组,对照组患者给予氯雷他定分散片治疗,观察组患者在上述治疗的基础上同时给予克拉霉素缓释胶囊、兰索拉唑肠溶胶囊和阿莫西林分散片,分析幽门螺杆菌的感染与慢性荨麻疹的关系。结果试验组患者幽门螺杆菌感染阳性率显著高于正常组,差异有统计学意义(P<0.05);观察组患者治疗效果显著优于对照组,差异有统计学意义(P<0.05)。通过临床随访3个月还发现,对照组复发率为28.95%,高于观察组的13.33%。结论梅州城区幽门螺杆菌感染与慢性荨麻疹存在一定的相关性,且抗幽门螺杆菌药物对于治疗慢性荨麻疹有一定的作用,临床上值得进一步推广应用。

Objective In order to explore the relationship between Helicobacter pylori infection and chronic urticaria in Meizhou city. Methods A total of 90 chronic urticaria-infected patients who were treated in our hospital from January 2016 to January 2017. They were compared with the normal group including 90 healthy subjects who had their physical check-up in hospital. As the experimental group, 90 case-studied patients were randomly divided into control group and observation group. The patients in the control group were treated with loratadine dispersible tablets. The patients in the observation group were given clarithromycin sustained-release capsules, lansoprazole enteric-coated capsules and Amoxicillin Dispersible Tablets in addition to loratadine dispersible tablets. The relationship between helicobacter pylori infection and chronic urticaria were then analyzed. Results The positive rate of helicobacter pylori infection in the experimental group was significantly higher than that in the normal group, with statistically significant difference （P〈0.05）. The therapeutic effect of the observation group was significantly better than that of the control group with statistically significant difference （P〈0.05）. The clinical recurrence rate in the control group was 28.95%, which was higher than the 13.33% recurrence rate in the observation group. Conclusion Helicobacter pylori infection is associated with chronic urticaria in the city of Meizhou, and the anti-helicobacter pylori drug has a certain effect in treating chronic urticaria. It is worthy to be further popularized in clinical practice.