小剂量糖皮质激素预防早产儿支气管肺发育不良效果观察

Observation of the Effects of Low Dose Glucocorticoid in the Prevention of Bronchopulmonary Dysplasia in Premature Infant

目的:探讨小剂量糖皮质激素预防早产儿支气管肺发育不良的临床疗效。方法:120例早产儿随机分为观察组(n=60)与对照组(n=60),观察组在基础治疗基础上加用小剂量地塞米松治疗,对照组仅给予基础治疗,对比两组早产儿支气管肺发育不良(BPD)发生率、呼吸机指标、吸氧时间等。结果:观察组BPD发生率为10.0%,显著低于对照组的66.7%(P<0.01);两组FiO_2、PIP、PEEP、MAP比较差异无统计学意义(P>0.05),观察组机械通气时间、吸氧时间均显著短于对照组(P<0.01)。结论:小剂量糖皮质激素可有效预防早产儿发生BPD,可使患儿尽早脱离呼吸机,安全高效,值得推广。

Objective： To discuss the clinical effects of low dose glucocorticoid in the prevention of BPD in premature infant.Method： 120 premature infants were randomly divided into the observation group（n=60） and the control group（n=60）, the observation group was treated with low dose of Dexamethasone based on the basic treatment, and the control group was treated with basic treatment only, then incident rate of BPD, ventilator index and time of oxygen inhalation were contrasted between the two groups.Result： The incidence rate of BPD in the observation group was 10.0%, significantly lower than 66.7% in the control group（P〈0.01）; there were no significantly differences in FiO2, PIP, PEEP, MAP between the two groups（P〉0.05）.Mechanical ventilation time, oxygen inhalation time in the observation group were significantly shorter than the control group（P〈0.01）.Conclusion： Low dose of glucocorticoid can effectively prevent BPD in premature infant , and can make the child wean from ventilator as early as possible, safe and efficient, it is worthy of promotion.