布地奈德联合N-乙酰半胱氨酸雾化吸入治疗小儿支气管肺炎的效果观察

Efficacy of N-acetylcysteine Combined with Budesonide in the Treatment of Bronchial Pneumonia in Childen through Aerosol Inhalation

目的:观察布地奈德联合N-乙酰半胱氨酸雾化液吸入治疗小儿支气管肺炎的效果。方法:选择2014年7月-2016年6月于笔者所在医院儿科就诊的小儿支气管肺炎患儿120例,随机分为A组和B组,两组患儿均接受常规基础综合治疗,在此基础上A组患儿接受雾化吸入布地奈德联合N-乙酰半胱氨酸雾化液,B组雾化吸入布地奈德,疗程均为4~7 d;比较治疗后两组患儿支气管肺炎各临床症状体征消失时间。结果:治疗后A组发热、咳嗽、气喘、啰音肺部和肺部X线阴影消失时间分别为(2.33±0.37)、(4.52±0.52)、(3.86±0.46)、(5.68±0.48)、(6.05±0.55)d,均显著短于B组,差异有统计学意义(P<0.05)。结论:布地奈德联合N-乙酰半胱氨酸雾化液吸入治疗小儿支气管肺炎的效果优于单纯吸入布地奈德,具有临床推广价值。

Objective： To observe the efficacy of N-acetylcysteine combined with Budesonide by aerosol inhalation in the treatment of the children with bronchial pneumonia.Method： 120 ehilden with bronchial pneumonia who enrolled the pediatrics department from July 2014 to June 2016 were randomly divided into group A and group B.The children in the group A received N-acetylcysteine combined with Budesonide by aerosol inhalation general besides basic treatmeul. And the children in the group B received Budesonide by aerosol inhalation besides the general basic treatment.Both of the treatment courses were 4-7 days; the clinical symptoms of the bronchial pneumonia as well as their durations were compared after the treatment.Result：After the treatment, the extinction time of fever, cough, asthma, pulmonary rales and X-ray shadow in group A were respectively （2.33 ± 0.37）d, （4.52 ± 0.52）d, （3.86 ± 0.46）d, （5.68 ± 0.48）d and （6.05 ± 0.55）d, which were shorter than those of the group B.And the differences were statistically significant（P〈0.05）.Conclusion： Budesonide combined with N-acetylcysleirle aerosol inhalation treatment of bronchial pneumonia in children is better than that with Budesonide.h has clinical development value.