柯萨奇病毒B组5型的研究进展

Progress in research on coxsackievirus B5

柯萨奇病毒B组5型(Coxsakievirus B5,CV-B5)引起的轻症包括上呼吸道感染、腹泻及手足口病(hand-footmouth disease,HFMD),也可引起病毒性脑炎、无菌性脑膜炎、胰腺炎、弛缓性麻痹、扩张性心肌炎等多种重症疾病,其中无菌性脑膜炎及病毒性脑炎呈全球范围分布,发病年龄主要集中于18岁以下的青少年人群,多发于夏秋季节。另外,CV-B5感染也是导致胰岛素依赖型(Ⅰ型)糖尿病的主要诱发因素之一,还可引起短暂性失语症和小儿急性横贯型脊髓炎等罕见临床症状。本文就CV-B5的病原学、流行病学、实验室诊断及动物模型等方面的研究进展作一综述。

Mild symptoms caused by Coxsackievirus B5 （CV-BS） include upper respiratory tract infection, diarrhea and hand-foot-mouth diseased （HFMD）. CV-B5 is also the pathogen of various severe diseases such as viral encephalitis, aseptic meningitis, pancreatitis, flaccid paralysis and dilated myocarditis. Aseptic meningitis and viral encephalitis are epidemic worldwide, which are mainly in the populations at ages of less than 18 years in summer and autumn. In addition, CV-B5 infection is also a major cause for insulin-dependent （type I ） diabetes as well as rare clinical symptoms such as transient aphasia and infantile acute transverse myelitis. This paper reviews the progress in research on the etiology, epidemiology, laboratory diagnosis as well as animal model of CV-BS.