抗IMP1自身抗体IgG在肝癌患者血清中的表达及其与临床病理参数的关系

Expression of serum anti-IMP1 autoantibody IgG in patients with hepatocellular carcinoma and its relationship with clinicopathological parameters

目的探讨肝癌患者血清中抗胰岛素样生长因子Ⅱ在mRNA结合蛋白1(IMP1)自身抗体IgG的表达及其与临床病理参数的关系。方法采用ELISA法检测120例肝癌患者(肝癌组)血清抗IMP1自身抗体IgG抗体,并与115例健康者(对照组)检测数据进行比较,分析血清抗IMP1自身抗体IgG抗体水平与肝癌患者临床病理参数的关系。结果肝癌组和对照组的血清抗IMP1自身抗体IgG水平分别为(1.512±0.685)、(1.080±0.301)μg/mL,肝癌组明显高于对照组,差异有统计学意义(P<0.001)。肝癌患者血清抗IMP1自身抗体IgG的表达水平与肿瘤大小、肿瘤分化程度、TNM分级、肝内转移有关(P<0.001);与年龄、性别、饮酒、是否感染HBV等无明显关系(P>0.05)。结论肝癌患者血清抗IMP1自身抗体IgG表达升高,检测肝癌血清抗IMP1自身抗体IgG有利于判断肝癌的恶性程度。

Objective To investigate serum anti-insulin-like growth factor-Ⅱ mRNA binding protein1(IMP1)autoantibody IgG expression in hepatocellular carcinoma(HCC)patient and its relationship with clinicopathological parameters.Methods ELISA method was used to detect serum anti-IMP1 autoantibody IgG in 120 cases of HCC,then the detection results were compared those in 115 healthy individuals(control group).The relationship between serum anti-IMP1 autoantibody IgG level with clinicopathological parameters in HCC patients was analyzed.Results The serum anti-IMP1 autoantibody IgG levels in the HCC group and control group were(1.512±0.685),(1.080±0.301)μg/mL respectively,the HCC group was significantly higher than the control group with statistical difference(P<0.001);serum anti-IMP1 autoantibody IgG in HCC patients was related with the tumor size,tumor differentiation degree,TNM grade and intrahepatic metastasis(P<0.001),and had no obvious relation with the age,sex,drinking and HBV infection(P>0.05).Conclusion Serum anti-IMP1 autoantibody IgG expression increased is increased in HCC patient.The detection of serum anti-IgG autoantibody IMP1 level in HCC is conducive to judge the malignancy degree of HCC.