不同药物对精神分裂症的疗效及对甲状腺素水平的影响

Effects of different drugs on schizophrenia and thyroxine levels

目的研究阿立哌唑、喹硫平和氨磺必利对精神分裂症的疗效及对甲状腺素水平的影响。方法收集医院收治的精神分裂症患者96例,采用随机表法将患者分为阿立哌唑组、喹硫平组和氨磺必利组,分别给予阿立哌唑、喹硫平和氨磺必利治疗2个月,比较3组的治疗效果、甲状腺素水平和不良反应。结果 3组的总有效率比较无统计学差异(P>0.05);3组治疗后的血清游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸、三碘甲状腺原氨酸和四碘甲状腺原氨酸水平均明显降低(P<0.05),且喹硫平组降低的最为明显(P<0.05),而阿立哌唑组与氨磺必利组之间无统计学差异(P>0.05);3组发生不良反应的临床表现特点不同,阿立哌唑组的不良反应主要为锥体外系反应,喹硫平组的不良反应主要为对血脂、血糖、肝功能及血压有影响,氨磺必利组主要为锥体外系反应及催乳素升高。结论阿立哌唑、喹硫平和氨磺必利对精神分裂症的临床治疗效果相当,且均能降低甲状腺素水平,以喹硫平降低最为明显,但不良反应特点各不相同。

Objective To study the effects of aripiprazole, quetiapine and amisulpride on schizophrenia and thyroxine levels. Methods A total of 96 patients with schizophrenia admitted to our hospital were selected and randomly divided into aripiprazole group, quetiapine group and amisulpride group. The three groups were treated with aripiprazole, quetiapine and amisulpride respectively for tw-o months. The effects, thyroxine levels and adverse reactions among the three groups were compared. Results The overall response rate （ORR） in the three groups showed no significant difference （P 〉 0.05）; the post-treatment levels of serum free triiodothyronine, free tetraiodothyronine, triiodothyronine and tetraiodothyronine in the three groups decreased greatly （P 〈0.05）; the decrease in the quetiapine group was the most significant（P 〈 0.05）; there was no significant difference between the aripiprazole group and the amisulpride group （P 〉 0.05）; the clinical features of the adverse reactions among the three groups were different; the adverse reactions in aripiprazole group mainly were extrapyramidal reactions, and those in quetiapine group mainly had effects on blood lipid, blood glucose and liver function while those in amisulpride group mainly were extrapyramidal reactions and prolactin elevation. Conclusion Aripiprazole, quetiapine and amisulpride have equivalent effects in the treatment of schizophrenia and can lower thyroxine levels. Quetiapine has the most significant effects in lowering thyroxine levels. The adverse reactions caused by the three kinds of drugs are different.