氨基酸对水热合成羟基磷灰石纤维形貌的影响

Effect of Amino Acids on Morphology of Hydrothermally Synthesized Hydroxyapatite Fibers

以Ca(NO_3)_2·4H_2O和(NH_4)_2HPO_4的水溶液为前驱体,基于生物矿化的基本原理,利用水热法制备结晶度较高的羟基磷灰石(HA)纤维,重点研究酸性氨基酸L-谷氨酸(Glu)、中性氨基酸L-苯丙氨酸(Phe)和碱性氨基酸L-赖氨酸(Lys)的添加对产物物相和形貌的影响。结果表明:添加这3种氨基酸均对产物的物相影响不大,制得样品的主要组成相都是HA,部分样品含有少量碳酸钙。3种氨基酸的加入均改变纤维沿c轴生长的趋势:加入Glu后得到球状形貌的HA,Lys的加入使得产物形貌变得不均匀,而加入Phe后得到分散性较好的棒状纤维。

Based on the basic principle of biomineralization, hydroxyapatite fiber （HAF） with high crystallinity was fabricated via a hydrothermal route with Ca（NO3）2·4H2O and （NH4）2HPO4 as the resources, respectively. Effects of the addition of acidic amino acid L-glutamic acid （Glu）, neutral amino acid L-phenylalanine （Phe） and basic amino acid L-lysine （Lys） on the phase composition and morphology of the obtained products were laid special emphasis on. The results show that the products obtained by using the three amino acids are all hydroxyapatite （HA） phase with minor CaCO3 in some samples. Meanwhile, all of the amino acids inhibit the growth of the fibers. Spherical morphology exists when Glu is added, the homogeneity of the fibers deteriorates with the addition of Lys. However, rod-like fibers with good uniformity can be obtained with the addition of Phe.