局部晚期乳腺癌中雄激素受体的表达及其临床意义

THE EXPRESSION LEVEL OF AR IN THE TISSUES OF LABC AND AND ITS CLINICAL SIGNIFICANCE

目的探讨局部晚期乳腺癌(LABC)组织中雄激素受体(AR)的表达水平及其与乳腺癌临床病理指标的关系。方法采用免疫组织化学方法(SP法)检测105例新辅助化疗前LABC病理组织中的AR的表达情况,并结合相关临床病理指标进行比较分析。结果 LABC组织AR的阳性表达水平均与ER表达水平有关,差异有统计学意义(P<0.05);AR还与瘤体大小、PR及分子分型有关(P<0.05),与年龄大小、组织学分级、淋巴结转移状况、HER2状态无关(P>0.05)。结论 AR在乳腺癌中较ER表达更广泛,AR阳性表达与乳腺癌的发展关系更为密切,有望成为新的治疗靶点及预后指标。

between the （AR） in the （LABC） and Objective To explore the relationship expression level of androgen receptor tissues of local advanced breast cancer the clinicopathologieal indexes of breast cancer. Methods The expression level of AR in 105 cases of LABC before neoadjuvant chemotherapy was evaluated by immunohistochemistry and the relationship between the expression level of AR and the clinicopathological indexes was analyzed. Results The positive expression level of AR in LABC tissues was related to ER expression level （P 〈0.05）. The expression level of AR was also associated with tumor size, PR and molecular typing（ P 〈0. 05）, but was not related to age, histological grade, lymph node metastasis and HER2 status （ P 〉0.05）. Conclusion AR is more widely expressed in the tissues of breast cancer than ER and the positive expression of AR is closely related to the development of breast cancer and may become a new therapeutic target and prognostic indicator.