外周血5-羟色胺及5-羟色氨酸水平与驾驶员事故倾向性关系研究

Study on the relationship between 5-HT,5-HTP levels in peripheral blood and drivers' accident proneness

目的探讨外周血5-羟色胺(5-hydroxytryptamine,5-HT)及5-羟色氨酸(5-hydroxytryptophan,5-HTP)水平与驾驶员事故倾向性的关系。方法采用病例对照研究方法,选取2008年1月~2012年12月中发生三次及三次以上同等责任交通事故的机动车驾驶员纳入病例组,按照同性别、同种驾驶车型以及年龄和驾龄相差不到2岁,同一时期且未发生过道路交通伤害(road traffic injuries,RTIs)的驾驶员作为对照组。结果病例组体内5-HT及5-HTP水平均低于对照组(均有P<0.05)。多因素Logistic回归分析结果显示,5-HT低水平及5-HTP低水平与机动车驾驶员事故倾向性有关(均有P<0.05)。结论驾驶员5-HT水平和5-HTP水平与其事故倾向性可能有关;5-HT和5-HTP水平高是驾驶员事故倾向性的保护因素。

Objective To investigate the relationship between 5-hydroxytryptophan（ 5HT）,5-hydroxytryptophan（ 5-HTP） level in peripheral blood and the drivers＇ accident proneness. Methods A case-control study was applied to this study. The motor vehicle drivers who had 3 or more times the same responsibility of road traffic accidents from January 2008 to December 2012 were selected as the cases,and other drivers who had not happened road traffic injuries during the same period with similar gender,vehicle type,age and driving years less than 2 years old as the control group. Results The levels of 5-HT and 5-HTP in the case group were lower than those in the control group（ all P〈0. 05）. Multivariate logistic regression analysis showed that the low level of 5-HT and the low level of 5-HTP were related to motor vehicle drivers＇ accident proneness（ all P〈0. 05）. Conclusions The driver accident proneness is related to the level of 5-HT and 5-HTP.5-HT and 5-HTP levels were protective factors of drivers＇ accident proneness.