摘要
近年来,磷酸二酯酶5(phosphodiesterase 5,PDE5)在神经系统疾病发生及发展过程中的作用备受关注,其抑制剂可发挥神经保护作用,机制与抑制PDE5后产生的抗中风、抗氧化、抗神经炎症及改善认知障碍等作用有关。该文结合国内外研究报道,系统地综述了PDE5抑制剂的神经保护作用及其相关作用机制。
In recent years, the role of phosphodiesterase 5（PDE5）has been highlighted in the development and progression of neurological disease.PDE5 inhibitors show significant effect of neruoprotection, which may be related with some effects such as resistance to stroke, anti-oxidation, inhibition of neuroinflammation and amelioration of cognitive deficits.Based on the domestic and overseas researches about PDE5, this review systematically summarized the neuroprotection of PDE5 and their related mechanisms.
作者
徐凡
雷鸣
龙隆
龚其海
高健美
XU Fan LEI Ming LONG Long GONG Qi-hai GAO Jian-mei(Colloge of Pharmacy Dept of Pharmacology and Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi Guizhou 563000, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2017年第5期603-606,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81560666)
贵州省淫羊藿开发利用科技创新人才团队[No黔科合人才团队(2015)4023号]
关键词
磷酸二酯酶5抑制剂
神经保护
抗中风
抗神经炎症
抗氧化
改善认知障碍
研究进展
phosphodiesterase 5 inhibitors
neuroprotection
anti-stroke
anti-neuroinflammation
anti-oxidation
amelioration of cognitive deficits
research progress
