狂犬病毒糖蛋白中多肽片段作为脑靶向药物载体的研究进展

Advances of polypeptide fragment of rabies virus glycoprotein as a brain-targeting carrier

狂犬病毒糖蛋白(rabies virus glycoprotein,RVG)中的多肽片段因其具有嗜神经性、血脑屏障通透性和生物安全性等优势,目前已成为研究最为活跃的脑靶向药物载体。RVG多肽片段与蛋白质或核酸连接后,可直接将其输送到脑内。此外,多肽片段还可与载药多聚物、纳米粒子或脂质体等偶联,引导后者快速进入脑内。RVG多肽片段为化合物、蛋白质、质粒、siRNA、miRNA等生物分子治疗脑部疾病提供了一个安全有效的途径。

Polypeptide fragment of rabies virus glycoprotein （RVG） has become one of the most popular polypeptides in drug delivery field, because of its advantages of neurotropiam, penetration of blood-brain barrier and biosafety. Polypeptide fragment of RVG can directly deliver proteins and nucleic acids into brain. Additionally, when polypeptide fragment of RVG couples with drug-loading polymers, nanoparticles or liposomes,it can mediate the latters into brain. The application of the RVG polypeptide fragment provides a safe and effective approach for the treatment of brain diseases with biomolecules, such as chem-icals, proteins, plasmids, siRNA, miRNA.