化瘀通阳方药对UC大鼠L/M值及P选择素影响的观察

Study on the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats

[目的]观察化瘀通阳方药对溃疡性结肠炎(UC)大鼠乳果糖/甘露醇值(L/M值)及P-选择素的影响,并探讨二者可能的关系。[方法]采用葡聚糖硫酸钠法进行UC大鼠模型的制作,分别予化瘀通阳方药灌肠及美沙拉嗪灌肠治疗,比较造模及治疗前后乳果糖/甘露醇值(L/M值)及P-选择素。[结果]造模后,大鼠L/M值及P-选择素较造模前明显增高,经化瘀通阳方药灌肠治疗,二者均明显减低,且与美沙拉嗪灌肠组相比,无统计学差异。[结论]化瘀通阳方药可有效降低UC模型大鼠L/M值及P-选择素,且与美沙拉嗪灌肠疗效相当。

[Objective] Observed the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats, while analysis the relationship between the intestinal permeability and P-selectin level. [Methods ] Ulcerative colitis model rats were made by DSS, mesalazine enema liquid and removing stasis and diffusing yang （RSDY） herbs in retention edema. The data of L/M and P- sel level were compared aftermolding and before and fater treatment. [Results] It was obviously found that L/M and P-sel level of the mod-el replication group significantly increased comparing with the data of the normal group. The datas of L/M and P-sel level of the group treated by mesalazine and RSDY herbs was obviously less than the data of the model control group, while there was no significant differ-ence between two groups. [Conclusion] Removing stasis and diffusing yang herbs retention enema can reduce L/M and P-sel level of the ulcerative colitis rats, while there was no statistically significant difference comparing with mesalazine group.