阿司匹林治疗老年急性脑梗死的最佳剂量观察

Observation of Optimal Dose of Aspirin in Treating Elderly Patients with Acute Cerebral Infarction

目的研究阿司匹林在治疗老年急性脑梗死治疗中的最佳剂量。方法回顾性分析自2013年7月至2016年7月我院收治的老年急性脑梗死患者128例作为研究对象,根据服用剂量分为为A组41例、B组48例、C组39例。3组患者入院后给予口服阿司匹林肠溶片,剂量分别为100、200、300mg/d,其余治疗相同,疗程均为14d,分别于治疗前后进行神经功能缺损评分(NIHSS),对比两组治疗效果及不良反应发生率;另外,进行为期半年的随访,进一步确定用药剂量。结果治疗后,3组NIHSS评分均有降低,且B组疗效明显高于于A组,差异有统计学意义(P<0.05);B组不良反应发生率低于C组(P<0.05)。结论 200mg/d剂量阿司匹林在治疗老年急性脑梗死中疗效和安全性的性价比高,值得临床推荐。

Objective To investigate the optimal dose of aspirin in treating elderly patients with acute cerebral infarction.Methods A total of 128 elderly patients with acute cerebral infarction admitted into our hospital from July 2013 to July 2016 were selected and analyzed retrospectively.According to the dose of aspirin,the subjects were divided into Group A （n=41）,Group B （n=48） and Group C （n=39）.100 mg,200 mg and 300 mg of aspirin enteric-coated tablets were given to the three groups respectively along with other same treatment for 14 days as a course.The NIHSS scores of the groups were determined before and after treatment respectively.The curative effect and incidence of adverse reactions were observed.In addition,a six-month follow-up was conducted to further determine the dosage.Results After treatment,the NIHSS scores of the 3 groups decreased.The curative effect of Group B was significantly better than that of Group A,with statistically significant difference （P〈0.05）.The incidence of adverse reactions of Group B was lower than that of Group C （P〈0.05）.Conclusion 200 mg/d of aspirin presents good performance in the efficacy and safety in the treatment of elderly patients with acute cerebral infarction,worth to be recommended for clinical application.