生物分子“盖帽”的介孔硅药物控释系统

Controlled drug release systems based on biomolecule-capped mesoporous silica nanoparticles

介孔硅纳米颗粒在药物控释系统中具有重要的科研价值和广阔的应用前景,这方面的研究已成为当今生物医药领域共同研究热点之一。而生物分子由于其生物相容性好、可降解、无毒副作用、靶向性强等优点被广泛应用于修饰介孔硅纳米颗粒。综述了用不同种类生物分子作为"帽子"修饰介孔硅的研究进展,着重介绍生物分子与介孔硅表面的连接作用方式及脱离机制。最后还对当前研究的热点及研究中存在的问题进行了评述与展望,希望为药物控释体系未来的研究提供借鉴与思路。

The research of MSN-based controlled drug release systems has been one of the current common interests of biomedicine and material science.Recently,biomolecules were extensively used to modify the mesoporous silica nanoparticles owning to their biocompatible,biodegradable,nontoxic and targeting properties.Herein,the research of MSN-based drug delivery systems,which were capped by various biomolecules was reviewed.It mainly was focused on the linked and responsive mechanisms between the biomolecules and the MSN.Finally,the difficulties in current research and the application prospect were discussed,which afford references and ideas for the future study in controlled drug release.