可降解镁合金支架的研究进展及应用

Current application and development of bioresorbable magnesium alloy stent

当前临床上主要应用的支架——药物洗脱支架,已显著降低再狭窄和置入金属支架后重复血运重建的需要,但应用具有相当多的限制,最明显的是由于异物的永久置入引起的慢性局部炎性反应,由金属笼引起的血管运动受限以及晚期的支架血栓形成的风险。生物可吸收支架(如镁合金支架)克服了这些限制,因为其在提供临时支撑作用、保护血管开放后可溶解、消失。本文针对近几年关于镁合金支架的最新进展,尤其是对临床试验及动物实验进行讨论,进而评价其当前应用、最新发展及其效果。

Currendy the commercial stents Drug eluting stents have significantly reduced restenosis and the need for repeat revascularization after implantation of the metal stent.However,most notably the chronic local inflammatory response due to the permanent implantation of foreign bodies,limited vasomotor motion caused by a metal cage,and the risk of late and very late stent thrombosis.Bioresorbable scaffolds overcome these limitations because they provide short term scaffolding of the vessel and then dissolve.The paper focus on fully degradable magnesium alloy stents,especially in clinical trials and animal experiments,discussing their current applications,recent developments and their effects.