托吡酯联合丙戊酸钠在难治性癫痫治疗中的应用价值及不良反应的研究

Study on the Value and Adverse Effects of Topiramate Combined with Sodium Valproate in the Treatment of Intractable Epilepsy

目的研究托吡酯联合丙戊酸钠在难治性癫痫治疗中的应用价值。方法选取2014年3月至2015年8月在大连市友谊医院神经内科就诊的100例难治性癫痫患者,随机分为对照组50例采取丙戊酸钠片治疗,试验组50例,在对照组的基础上使用托吡酯联合治疗,比较两组患者的有效率以及药物不良反应情况。结果有效率方面试验组高于对照组,差异有统计学意义(P<0.05),不良反应率方面试验组低于对照组,差异有统计学意义(P<0.05)。结论使用托吡酯片联合丙戊酸钠治疗难治性癫痫,临床有效率高,不良反应率低,值得在临床推广。

Objective The application value of topiramate combined with sodium valproate in the treatment of refractory epilepsy. Methods A total of March 2014 to August 2015 in Dalian Friendship Hospital neurology clinic of 100 cases of refractory epilepsy patients, were randomly assigned to control group of 50 cases taking sodium valproate tablets in the treatment of experimental group of 50 cases. In the control group based on the use of topiramate in the treatment, compared two groups of patients with efficiency and adverse drug reactions. Results The effective rate of experimental group was higher than the control group, the difference was statistically significant（P〈0.05）, the adverse reaction rate of the test group was lower than the control group, the difference was statistically significant（P〈0.05）. Conclusion The use of topiramate combined with sodium valproate in treatment of intractable epilepsy, the clinical effective rate high, the low rate of adverse reactions, worth in clinical promotion.