分子信号通路在瘢痕疙瘩中的研究进展

Progress of molecular signaling pathways in keloid

瘢痕疙瘩(KD)是皮肤创伤的异常修复而产生的一种良性的皮肤增生性肿瘤,其病因机制尚不清楚,其治疗一直是整形外科界的难题。近些年,从分子信号通路去研究瘢痕疙瘩的形成及防治方法受到广泛关注,逐步成为瘢痕疙瘩的研究热点。本文将对分子信号通路在瘢痕疙瘩发病机制及治疗研究进展做一综述。

Keloids represent benign fibroproliferative tumors originating in response to the abnormal repair of trauma to the skin. However, its pathogenesis is not clear and the treatment is still a difficult problem to plastic surgery. It has been widely concerned through molecular signaling pathways to detect the formation and prevention of keloid in recent years. Also it becomes a hot topic of keloid gradually in research. This review would discuss the pathogenesis and treatment of keloid by molecular signaling pathways.