自拟解郁化痰汤合左洛复治疗肝郁痰阻型抑郁60例疗效观察

Effect of Huatan-jieyu Decoction combined with sertraline in treatment of Liver stagnation and phlegm type depression:A Clinical observation study

目的:对自拟解郁化痰汤合左洛复治疗肝郁痰阻型抑郁的疗效和安全性进行分析。方法:选取2013年5月~2014年7月江苏省中医院脑病中心收治的肝郁痰阻型抑郁患者60例.随机分为两组,各30例。研究组行解郁化痰汤合左洛复治疗,对照组行左洛复治疗,疗程8周,观察比较两组治疗后的临床效果和不良反应情况。结果:治疗前两组患者HAMD评分比较差异无统计学意义(P>0.05),治疗后两组患者HAMD评分均明显降低,且研究组降低更为明显,差异有统计学意义(P<0.05)。研究组患者治疗后总有效率为96.7%,明显高于对照组的60%,差异具有统计学意义(P<0.05)。结论:解郁化痰汤合左洛复治疗肝郁痰阻型抑郁的临床疗效较好,且无严重毒副作用,安全性较高,是治疗抑郁的良好方法。

Objective： To investigate the efficacy and safety of Huatan-jieyu Decoction in the treatment of Liver stagnation and phlegm type depression in combination with sertraline （trade name： Zoloft）. Methods： A total of 60 patients, enrolled at the Encephalopathy Center of Jiangsu Province Hospital of Traditional Chinese Medicine May from May 2013 to July 2014, were randomly assigned to two treatment groups （n-30 per group）. The study group （combination treatment group） received Huatan-jieyu Decoction combined with sertraline, while the control group （Zoloft alone） received Zoloft only. The efficacy and adverse effects of treatment were recorded and compared between the two groups. Results： There was no significant difference in the HAMD scores between the two groups before treatment （P〉0.05）. After treatment, the HAMD scores of both groups were significantly decreased, and the study group showed more significantly decrease, which was statistically significant from that of control group （P〈0.05）. The total effective rate was 96.7% in the study group, which was significantly higher than that of the control group （60%, P〈0.05）. ConcIusion： Combination of Huatan-jieyu Decoction with sertraline offered better clinical efficacy in the treatment of Liver stagnation and phlegm type depression than single sertraline, and this combination has satisfactory safety, providing a potentially promising method to treat depression.