摘要
目的:观察蒙药嘎木朱尔散对压疮缺血再灌注损伤模型大鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量的影响,探讨蒙药嘎木朱尔散治疗压疮的作用及其机制。方法:将32只SD大鼠随机分为4组,每组8只。正常组、模型组、云南白药组和嘎木朱尔组,治疗7d,最后1次给药后,10%水合氯醛麻醉大鼠,腹主动脉采集血液,测定大鼠血清SOD和MDA含量。结果:蒙药嘎木朱尔组与云南白药组皆可提高大鼠血清SOD含量(P<0.01),降低MDA含量(P<0.01),蒙药嘎木朱尔组和云南白药组比较无明显差异(P>0.05)。结论:蒙药嘎木朱尔散对模型大鼠血清具有抗氧化作用。
Objective： To observe the effect of serum SOD and MDA contents of on pressure ulcer with ischemia-reperfusion injury in rats,and to explore its mechanism for treatment of pressure ulcers. Methods： 32 SD rats were randomly divided into four groups,each group of eight. Normal group,model group,yunnanbaiyao group and gamuzhuer group,treating for 7 days,after the last dose,10% chloral hydrate anesthesia in rats,abdominal aortic blood was collected,to determine serum SOD and MDA in rats. Results： SOD contents of yunnanbaiyao group and gamuzhuer group were significantly increased（ P〈0. 01）. MDA contents were significantly decreased（ P〈0. 01.There was no statistically difference between Hatageqi-7 group and Yunnan Baiyao group（ P〉0. 05. Conclusion：Gamuzhuer powder had antioxidant effect on pressure ulcer with ischemia-reperfusion injury rats.
作者
包苏布道
阿古拉
Baosubudao Agula(Beijing University of Chinese Medicine , Beijing 100029 Inner MongoliaMedical University, Inner Mongolia Hohhot 010110)
出处
《中国民族医药杂志》
2017年第3期52-53,共2页
Journal of Medicine and Pharmacy of Chinese Minorities
基金
内蒙古医科大学青年创新基金项目“蒙药嘎木朱尔对压疮缺血再灌注损伤大鼠血清SOD、MDA的影响”项目编号:YKD2015QNCX010
关键词
蒙药
嘎木朱尔
缺血再灌注损伤
Mongolian medicine pharmacy
Gamuzhuer
Ischemia-reperfusion injury
