相同基因条件下牙周治疗与动脉硬化的相关性

The relationship between periodontitis and arterial sclerosis without genetic confounding

目的 :探讨在排除基因差异后,牙周基础治疗对牙周病患者动脉硬化的影响,比较治疗前、后动脉硬化指标的改变,分析两者之间的关系。方法:按一定标准选取2013年9月—2015年6月在门诊就诊的同卵双生双胞胎患者52对104例,其中24对48例为牙周健康患者,28对56例为牙周病患者。将每对双胞胎分配到不同组别中,即A组(24对48例牙周健康)、B组(28例牙周病)、C组(28例牙周病,基因型同B组),C组为治疗组,A、B为对照组。检测术前、术后6周、12周患者血清C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平以及颈动脉内膜中层厚度(IMT)。采用SPSS17.0软件包对组间差异进行F检验。结果:治疗前,牙周病组(B组和C组)各项指标均显著高于健康组(A组);治疗后,A、B组各项指标无显著改变,C组各项指标均显著低于治疗前(P<0.05)。结论:牙周病对动脉硬化有一定促进作用,且这种作用可独立于基因型作用而存在,积极的牙周治疗可在一定程度上阻止动脉硬化的发生与发展。

PURPOSE： The aim of this study was to evaluate periodontitis as a significant risk factor related to arterial sclerosis after eliminating genetic confounding. METHODS： Fifty two monozygotic twin pairs, 104 patients, were divided into 3 groups, group A： 24 pairs, 48 healthy people, as the blank group; group B： 28 patients with periodontitis, as the control group; group C： 28 patients with periodontitis, as the treatment group. The sample in group B and C had the same gene type. The index of CRP, IL-6, TNF-α and IMT were detected before treatment, 6 and 12 week after treatment. The data were analyzed using SPSS 17.0 software package. RESULTS： The index of CRP, IL-6, TNF-α and IMT decreased after treatment in group C, there was no significant change in group A and B at each check point. CONCLUSIONS： Periodontitis can promote the development of sclerosis without the intervening of gene.