咳喘停药贴穴位贴敷治疗合并过敏性鼻炎哮喘复发临床研究

Clinical Study of Kechuanting Paste Acu-Point Sticking Therapy on the Relapse of Asthma with Allergic Rhinitis

目的:探讨咳喘停药贴穴位贴敷对处于缓解期的合并过敏性鼻炎哮喘患者的疗效及其血清mi R-95、mi R-34a-5p含量的影响。方法:将夏季穴位贴敷哮喘患者分为合并过敏性鼻炎组36例,单纯哮喘组34例,两组皆用咳喘停药贴穴位贴敷治疗,35例健康人作为健康组,电话随访患者复发情况,以及采用RT-PCR法观察三组治疗前后血清mi R-95以及mi R-34a-5p水平变化情况。结果:(1)与治疗前比较,治疗后两组哮喘患者的同期发作次数显著降低。(2)治疗前后,合并过敏性鼻炎组及单纯哮喘组的血清mi R-95、mi R-34a-5p水平均显著高于健康组(P<0.05)。与治疗前比较,两组哮喘患者治疗后的血清mi R-95、mi R-34a-5p水平有下降趋势,但差异无统计学意义(P>0.05)。结论:咳喘停药贴穴位贴敷可改善合并过敏性鼻炎的哮喘患者复发情况,与单纯哮喘组疗效相当,并且可下调血清mi R-95、mi R-34a-5p水平。

Objective：To investigate the effect of Kechuanting paste acu-point sticking on relapse of asthma with allergic rhinitis arid on serum miR-95,miR-34a-5p. Methods：There were 36 asthma patients with allergic rhinitis as the asthma with rhinitis group,34 asthma patients in the asthma group,and 35 healthy people in the healthy group. The first 2 groups were treated with Kechuanting paste acu-point sticking. Telephone fol- low-up was performed to determine the recurrence,and RT-PCR was applied to detect miR-95 and miR-34a-5p levels before and after treatment. Results：（1）Compared with before treatment,in the first two groups the relapse was significantly reduced. （2）Before and after the treatment,levels of serum miR-95 and miR-34a-5p of the first two groups were significantly higher than the healthy group（P〈0.05）. Compared with before treatment, levels of serum miR-95 ,miR-34a-5p in the two groups have decreased,but there was no significant difference （P〉0.05）. Conclusion：Kechuanting paste acu-point sticking can reduce allergic rhinitis relapse in asthma patients with allergic rhinitis,similar to asthma patients,and can reduce serum miR-95,miR-34a-5p levels.