癫狂梦醒汤联合心理干预治疗轻微型肝性脑病临床研究

Clinical Study of Using Diankuang Mengxing Decoction Combined with Psychotherapy to Treat Minimal Hepatic Encephalopathy

目的:观察癫狂梦醒汤联合心理干预治疗轻微型肝性脑病的临床疗效。方法:将80例轻微型肝性脑病的患者随机分为治疗组与对照组各40例。治疗组在对照组治疗基础上给予癫狂梦醒汤口服,每次100 m L,每日2次,同时联合心理干预治疗;对照组给予乳果糖口服液口服,每次30 m L,每日3次。治疗10周后统计脑电图、血氨、数字连接试验(NCT)、数字符号试验(DST)、听觉事件相关电位P300的变化。结果:治疗组与对照组治疗后脑电图、血氨、NCT、DST、听觉事件相关电位P300比较差异均有统计学意义(P<0.05)。结论:癫狂梦醒汤联合心理干预对轻微型肝性脑病有一定的治疗作用,且不良反应小。

Objective：To observe the clinical efficacy of Diankuang ~lengxing decoction combined with psy- chotherapy in the treatment of mild hepatic encephalopathy. Methods：Eighty patients with mild hepatic en- cephalopathy were randomly divided into treatment group and control group,40 cases in each group. The control group was given oral administration of Chinese herbal medicine,Diankuang Mengxing decoction based on the control group,each time 100mL,2 times a day,combined with psychotherapy. And the control group was given oral administration of lactulose oral solution,each time 30 mL,3 times a day. The changes of electroencephalo graph（EEG）,blood ammonia,NCT,DST and auditory event-related potential P300 were mea- sured after 10 weeks of treatment. Results：There were significant differences in EEG,blood ammonia,NCT, DST and auditory event potential P300 between the treatment group and the control group（P〉0.05）. Conclu- sion：The combination of Diankuang Mengxing decoction and psychotherapy has a certain therapeutic effect on mild hepatic encephalopathy with mild adverse reaction.