胃肠道微生态系统与胃食管反流病关系的研究进展

Advances in Study on Gut Microbial Ecosystem and Gastroesophageal Reflux Disease

胃肠道中存在着人体内最复杂的微生态系统,其微生态平衡对人体健康具有重要作用。胃食管反流病(GERD)的发生、发展与食管、胃、肠微生态密切相关,胃肠道微生态系统的变化可能通过多种途径参与诱导食管黏膜炎症反应和下食管括约肌(LES)松弛、增加胃内压力、延迟胃排空,最终引发或加重胃食管反流。本文就胃肠道微生态系统与GERD关系的研究进展作一综述。

Gastrointestinal tract contains the most complicated microbial ecosystem of the human body, and balance of microbial ecosystem has been proved to play an important role in human health. Gastroesophageal reflux disease （GERD） is closely related to the esophageal, gastric and intestinal microecology. It has been revealed that alterations in gut microbial ecosystem may induce mucosal inflammation, relax lower esophageal sphincter （LES）, increase intragastric pressure and delay gastric emptying via various pathways and subsequently cause or exacerbate gastroesophageal reflux. In this article, the advances in study on gut microbial ecosystem and GERD were reviewed.