氧化应激和自噬在动脉粥样硬化中的作用研究新进展

The new progress of the role of oxidative stress and autophagy in atherosclerosis

动脉粥样硬化是一种累及全身大、中动脉的多因素、多步骤失调性病变,是各种心脑血管疾病的病理基础。动脉粥样硬化的发病机制目前仍不完全清楚。近年来国内外越来越多的证据表明,氧化应激和自噬是动脉粥样硬化形成和发展的关键因素。氧化应激通过直接氧化损伤和间接信号介导损伤促进了动脉粥样硬化的发生发展;自噬具有抗动脉粥样硬化和促动脉粥样硬化的双重作用;二者又有错综复杂的交联关系。本文分别从氧化应激在动脉粥样硬化中的作用、自噬在动脉粥样硬化中的作用、氧化应激和自噬在动脉粥样硬化中的交联作用三方面展开论述,为疾病的认识和治疗提供新思路。

Atherosclerosis, the pathological basis of various kinds of cardiovascular diseases, is a kind of disease of multifactorial and multistep disorder involving the whole-body large- and medium-sized arteries. The pathogenesis of atherosclerosis is still not fully understood. There is growing evidence that oxidative stress and autophagy are two key factors in the formation and development of atherosclerosis in recent years at home and abroad. Oxidative stress accelerates the occurrence and development of atherosclerosis through direct oxidative damage and indirect signal mediated injury ; Autophagy possesses double functions of resisting and promoting the atherosclerosis. While there is a complicated relationship of cross-linking between them. This paper, specified in the following three aspects separately, that is, the roles of oxidative stress, autophagy, and the complicated relationship of cross-linking between them in atherosclerosis, will provide a new way of thinking in understanding and treatment of the disease.