摘要
目的了解系统糖皮质激素治疗前后大疱性类天疱疮(BP)患者糖尿病患病情况及临床特点。方法回顾性分析2005年6月-2016年2月北京医院皮肤科和北京大学第三医院皮肤科收治的45例BP患者的临床资料,并与同期90例接受系统性应用糖皮质激素治疗的湿疹患者进行对照分析。结果系统性应用糖皮质激素治疗前,BP组与湿疹组诊断为2型糖尿病者与非2型糖尿病者的性别构成和年龄组成及2型糖尿病患病比例的差异均无统计学意义(P均>0.05)。系统性应用糖皮质激素治疗8周后,BP组诊断为2型糖尿病者平均年龄较非糖尿病者大(P<0.05),性别差异无统计学意义(P>0.05),且BP组患糖皮质激素诱导性糖尿病(GC-DM)比例较湿疹组高(P<0.05),BP组和湿疹组患GC-DM者均较未患GC-DM者的年龄大(P<0.05)。有代谢综合征病史的BP患者较无该病史者更易发生GC-DM(P<0.05)。结论 BP患者较湿疹患者更易发生GC-DM,且年龄越大的BP患者和既往有代谢综合症病史的BP患者更易发生GC-DM。
Objective To investigate the prevalence of diabetes in patients with bullous pemphigoid(BP)treated with glucocorticoids(GC).Methods A retrospective analysis was performed in 45 BP patients and 90 cases of eczema treated with systemic GC at Beijing Hospital and No.3 Hospital of Peking University from June 2005 to February 2016.Results Before systemic GC treatment, BP and eczema patients were similar with respect to the morbidity of type 2 diabetes in gender and age.After 8-week treatment, both BP and eczema patients with type 2 diabetes were older than those without type 2 diabetes(P〈0.05); Gender did not affect the development of type 2 diabetes associated with GC treatment in BP patients; More BP patients developed type 2 diabetes in comparison with eczema patients; BP patients with metabolic syndrome(MS)were more susceptible to develop type 2 diabetes than those without MS(P〈0.05).Conclusion In comparison with eczema patients, BP patients, particularly the older and those with MS, are more likely to suffer from GC- type 2 diabetes.
出处
《中国皮肤性病学杂志》
CSCD
北大核心
2017年第5期501-504,共4页
The Chinese Journal of Dermatovenereology
关键词
大疱性类天疱疮
2型糖尿病
糖皮质激素
激素诱导性糖尿病
代谢综合征
湿疹
Bullous pemphigoid
Type 2 diabetes
Glucocorticoid therapy
Glucocorticoid-induced diabetes melhtus
Metabolic syndrome
Eczema