真皮中层弹性组织溶解症1例

A Case of Mid-dermal Elastolysis

患者女,36岁。躯干、四肢皮肤浅色扁平丘疹20年。皮损发展缓慢,无明显症状。皮肤科情况:躯干、四肢皮肤出现大小不一的浅色扁平丘疹,其走向与皮纹方向一致,并伴有双上臂后侧出现以毛囊为中心的针帽大丘疹。部分皮疹融合成斑块。扁平皮疹处组织病理检查:表皮萎缩变薄;真皮胶原纤维变细,排列疏松。阿新兰染色:真皮未见明显黏蛋白沉积。弹力纤维染色:真皮中部可见弹力纤维明显减少或消失。诊断:真皮中层弹性组织溶解症。

A 36-year-old woman presented with a 20- year history of light fiat papules on the trunk and limbs, The le- sions developed slowly and were asymptomatic. Skin examination revealed multiple irregularly sized light fiat papules on the trunk and limbs along Langer＇ s lines, multiple pin cap-sized perifollicular papules .on the posterior upper arm. Part of papules merged into plaques. Pathological examination of biopsy showed epider- mal atrophy and thinning, and thinned collagen fibers arranged loosely in the dermis. Aleian blue staining re- vealed no mucoprotein in the dermis. Verhoeff-van Giesen＇s Staining showed almost complete absence of elas- tic fibers in the mid dermis. Based on the above findings,the diagnosis was made as mid-dermal elastolysis.