摘要
以马来酸阿塞那平为例,分别用混悬液法、溶剂加热冷却法、饱和溶液缓慢沉淀法、反溶剂沉淀法、高压法、化合物加热/冷却法来制备寻找其不同的晶体形态。用不同的分析手段来鉴别产生的不同形态化合物的晶型。这几种常见的制备不同晶型的方法对于企业开发其他化合物寻找不同晶型有很好的借鉴意义。
Set Asenapine Maleate as an example, the different crystal forms were prepared with the slurry method, solvent-thermal heating/cooling method, slow precipitation from saturated solutions method, the anti-solvent method, the high pressure method, thermal heating/cooling method and grinding method. At the same time identify the crystalline form of the different forms of the compound produced. These common methods of preparation of different crystal forms have a good reference value for company to find new crystal of other compounds.
作者
韩锦伟
耿红超
黄艳
霍学兵
HAN Jin-wei GENG Hong-chao HUANG Yah HUO Xue-bing(Fuyang Sineva Materarial Techonology Co., Ltd., Fuyang 236000, Chin)
出处
《安徽化工》
CAS
2017年第2期72-76,共5页
Anhui Chemical Industry
关键词
马来酸阿塞那平
晶型制备
晶体形态
Asenapine Maleate
crystal preparation
crystal morphology