早发型重度子痫前期的期待治疗对母婴结局的影响

Effect of Expectant Management on the Maternal Infantile Outcome in Early Onset Severe Preeclampsia

目的:探究早发型重度子痫前期的期待治疗对母婴结局的影响。方法:选择我院于2015年2月~2016年4月期间收治的76例早发型重度子痫前期患者为研究对象,按发病孕周将所有患者分为两组,A组40例(孕周<31周),B组36例(孕周≥32周)。比较两组患者发病时孕周、期待治疗时间、终止妊娠孕周、分娩方式、并发症发生情况、围产儿预后情况。结果两组分娩方式对比,无明显差异(P>0.05);B组发病时孕周、期待治疗时间、终止妊娠孕周均明显高于A组,差异显著(P<0.05);B组胎盘早剥、产后出血、低蛋白血症、弥散性血管内凝血等并发症发生率明显低于A组,差异显著(P<0.05);B组胎儿宫内生长受限、围产儿死亡、新生儿窒息、新生儿死亡均明显低于A组,差异显著(P<0.05)。结论与孕周较长患者相比,孕周短的早发型重度子痫前期患者并发症发生率较高,治疗时间较短,且围产儿预后差;临床应早期给予患者诊治,尽量延长孕周,并适时给予终止妊娠,可有效降低母婴不良结局的发生。

Objective： To explore the effect of expectant management on the maternal infantile outcome.in early onset severe preeclampsia （ESPE）. Methods： In total, 76 pregnant women with early onset severe preeclampsia were admitted and treated in our hospital from February 2015 to April 2016 as the objects of study. According to illness during gestational weeks, they were divided into A group（〈31 weeks） and B group （ ≥32 weeks）. These two groups were compared in illness during gestational weeks, expectant treatment time, timing delivery, delivery mode, complications, and perinatal prognosis. Results： （1） There was no significant difference in the delivery mode between the two groups （P〉0.05）. （2） In B group, the illness during gestational weeks, expectant treatment time, timing delivery were significandy higher than those in A group （P 〈 0.05）. （3） The complications in B group was significantly lower than in A group such a placental abruption, postpartum hemorrhage, hypoproteinemia, and disseminated intravascular coagulopathy （P〈0.05）. （4） In B group, fetal growth restriction, perinatal death, neonatal asphyxia, new born death were significantly lower than those in A group （P 〈 0.05）. Contusions： Patients with illness during gestational weeks showed a relatively high incidence of complications, with shorter treatment time and poorer perinatal prognosis. In addition, early diagnosis of ESPE should be actively treated, extend gestational period efficiently, terminate the pregnancy timely, in order to reduce adverse maternal infantile outcome.