缬沙坦联合氢氯噻嗪治疗老年高血压患者的疗效观察

Efficacy of Valsartan Combined with Hydrochlorothiazide for Senile Hypertension

目的:探讨缬沙坦与氢氯噻嗪联合应用于老年高血压治疗中的临床疗效及安全性。方法:选择我院于2014年3月~2016年3月期间诊治的老年高血压患者200例,用随机数字方法将其分为了研究组(100例)与对照组(100例)。对照组仅给予缬沙坦治疗,研究组同时给予缬沙坦与氢氯噻嗪治疗,对比两组的临床效果与不良反应情况。结果:研究组与对照组的总有效率分别为96.00%、88.00%,组间比较存在显著差异(Ρ<0.05);不良反应发生率分别为5.00%、9.00%,差异不明显(Ρ>0.05)。结论:缬沙坦与氢氯噻嗪联合治疗老年高血压,疗效显著、不良反应少。

Objective： To investigate the clinical efficacy of valsartan combined with hydrochlorothiazide for senile hypertension and its safety. Methods： In total, 200 senile patients with hypertension were admitted and treated in Lushan People＇s Hospital from March 2014 to March 2016. They were randomly divided into control group and test group with 100 patients in each group. Patients in control group were treated with valsartan, while patients in test group were treated with valsartan combined with hydrochlorothiazide. The incidence of adverse reactions was compared between the two groups.Results： The total effective rate in test group （96.00%） was significantly higher than that in control group （88.00%） （P〈0.05）.There was no significant difference in adverse reactions between test group （5.00%） and control group （9.00%） （P〉0.05）. Conclusions： Valsartan combined with hydrochlorothiazide is an effective antihypertensive with fewer side effects for senile hypertension.