大分割放疗治疗中央型肺癌的疗效评价

Control study of hypofractionated three-dimensional conformal radiotherapy in advanced centrally located non-small cell lung cancer

目的探讨三维适形大分割放疗治疗晚期中央型非小细胞肺癌的疗效和安全性。方法收集2009年1月至2012年4月宜宾市第二人民医院收治的72例中央型ⅢA~Ⅳ期非小细胞肺癌患者为研究对象,其中35例接受三维适形大分割放疗(60 Gy/15 f/3 w),37例接受常规分割放疗(60 Gy/30 f/6 w),比较分析两组患者的近期疗效、生存率及放疗不良反应发生率。结果大分割放疗组与常规分割放疗组的治疗有效率分别为80.0%、56.8%(P<0.05);1、2、3年生存率分别为82.9%和45.9%(P<0.05)、40.0%和29.7%(P>0.05)、22.9%和16.2%(P>0.05);不良反应发生率两组差异无统计学意义(P>0.05),未发生严重的放疗毒性反应。结论三维适形大分割放疗治疗晚期中央型非小细胞肺癌具有较好的近期疗效,放疗副反应能够耐受。

Objective To observe the efficiency and adverse effects of hypofractionated three-dimensional conformal radiotherapy （3DCRT） in advanced centrally located non-small cell lung cancer（NSCLC） . Methods From January 2009 to April 2012, 72 patients with advanced centrally located non-small cell lung cancer were treated with hypofractionated three-dimensional conformal radiotherapy （3DCRT） or conventional fractionated radiation therapy in the authors＇ affiliated hospital. All patients were randomly divided into two groups： 35 cases in the hypofractionated three-dimensional conformal radiotherapy group（ DT ：60 Gy/15 f/3 w） and 37 cases in the conventional fractionated radiation therapy group （DT： 60 Gy/30 f/6 w）. Results The short-term effective rate in the hypofractionated conformal radiotherapy group was 80. 0%, whereas the conventional fractionated radiation therapy group was with a total response rate of 56. 8% （P 〈 0. 05）. One-year survival, 2-year survival and 3-year survival rates of the two groups were 82. 9% and 45.9% （ P 〈 0. 05 ） , 40. 0% and 29. 7% （P 〉0. 05）, 22. 9% and 16. 2% （P 〉0. 05）, respectively. The incidences of adverse events were similar （ P 〉 0. 05 ）. No significant radiation toxicity occurred. Conclusions Hypofractionated three-dimension- al conformal radiotherapy using 60 Gy in 15 fractions is feasible and result in smoothy control.