广西艾滋病合并结核病双重感染情况及其影响因素分析

Study on HIV-TB coinfection in Guangxi and its influenced factors

目的调查广西艾滋病(HIV/AIDS)合并结核病(TB)双重感染情况,并分析其影响因素。方法收集2013年广西某传染病医院就诊的1 086例艾滋病患者的临床资料,分析其HIV/TB双重感染情况,运用二分类Logistic回归模型进行TB/HIV双重感染影响因素分析。结果 1 086例艾滋病患者中,HIV/TB双重感染527例(48.53%)。其中单纯肺结核245例(46.49%),肺结核合并肺外结核197例(37.38%),单纯肺外结核85例(16.13%)。多因素Logistic回归分析显示,男性患者(OR=1.472,95%CI=1.056~2.054)、>50岁者(OR=1.477,95%CI=1.111~1.964)、CD4+T淋巴细胞计数低者(OR=1.347,95%CI=1.022~1.776)及血小板计数较高者(OR=2.079,95%CI=1.360~3.179)更易感染TB。结论广西HIV/AIDS患者TB的感染率较高,性别、年龄、血小板和CD4+T淋巴细胞计数是其感染TB的危险因素,应根据患者的不同临床特征制定相应的防治措施。

Objective To investigate tuberculosis （TB） and human immunodefieieney virus （HIV） eoinfection in Guangxi and its influneneed factors. Methods 1 086 HIV/AIDS patients from a certain hospital for infectious diseases of Nanning, Guangxi were screened for TB/HIV coinfeetion. Logistic regression model was performed to analyze the factors that influenced TB and HIV coinfection. Results 48.53% of the 1 086 HIV/AIDS patients were eoinfeeted with TB and HIV in which simple TB accounted for 46. 49% , TB complicated with extrapulmonary TB accounted for 37. 38% , and simple extrapulmonary TB accounted for 16. 13%. Multivariate logistic regression analysis showed that there were four major risk factors of getting TB topped the list-male patients （ OR = 1. 472, 95% CI = 1. 056 -2. 054） , more than fifty years old（ OR = 1. 477, 95% CI = 1. 111 - 1. 964）, lower CD4^＋ T lymphocytes cell count（ OR = 1. 347, 95% CI = 1. 022 - 1. 776 ） and higher platelet count （ OR = 2. 079, 95% CI = 1. 360 - 3. 179）. Conclusion The infection rate of TB is high in the HIV patients of Guangxi. Sex, age, CI）4 ＋ T lymphocytes cell count and platelet count are the risk factors for HIV/AIDS patients. Different preventing measures should be given to the patients according to their different clinical features.