四磨汤口服液在食管癌术后加速康复中作用的研究

The effect of Simotang oral liquid on rehabilitation after the operation of esophageal cancer

目的探讨四磨汤口服液在食管癌术后加速康复中对胃肠功能恢复的影响。方法将110例食管癌手术患者随机分为四磨汤组和生理盐水组各55例,两组均给予常规营养支持治疗。四磨汤组术后经鼻肠营养管注入四磨汤口服液,生理盐水组给予等容量温生理盐水(安慰剂)治疗,观察并比较两组患者胃肠功能恢复情况。结果四磨汤组术后肛门首次排气时间、肠鸣音恢复时间均显著短于生理盐水组(P<0.05),但两组肛门排便时间差异无统计学意义(P>0.05);四磨汤组血浆胃动素(MTL)和胃泌素(GAS)水平与生理盐水组比较差异有统计学意义(P<0.01);两组MTL、GAS浓度术后随着时间推移而升高,组内不同时间点水平差异均有统计学意义(P<0.01),分组与时间之间有交互作用(P<0.01)。结论四磨汤口服液在食管癌患者术后可有效促进胃肠功能恢复,加速康复,效果明确,具有较高的临床应用价值。

Objective To investigate the effect of Simotang oral liquid on the recovery of gastrointestinal function after the operation of esophageal cancer. Methods 110 patients with esophageal cancer were randomly divided into the Simotang group and the saline group, with 55 cases in each group. The conventional nutritional support treatment was given to the two groups. Besides, the Simotong group received Simotang oral liquid via nasojejunal tube after the operation and the saline group were given matched saline（placebo） treatment. The recovery of gastrointestinal function was compared between the two groups. Results The postoperative anal exhaust time and the bowel sound recovery time in the Simotang group were significantly shorter than those in the saline group （ P 〈 0. 05 ）, however there was no significant difference in the defecation time between the two groups （ P 〉 0. 05 ）. There were significant differences in the levels of plasma motilin（MTL） and gastrin（GAS） between the two groups（ P 〈0.05 ）. The concentrations of MTL and GAS increased over time after the operation, in both of the two groups, with significant differences among different time points （ P 〈 0. 05 ）, and grouping factors interacted with time factors （ P 〈 0. 05 ）. Conclusion Simotang oral liquid can effectively promote recovery of the gastrointestinal function, and accelerate healing of the body in the patients with esophageal cancer after the operation.