骨关节炎临床表现特点及沉默信息调节因子1在其发病中的作用

Clinical manifestations of osteoarthritis and the role of silent information regulation 1 in the pathogenesis of osteoarthritis

背景:研究发现一些功能性基因的功能变化是引发骨关节炎的调控环节,而年龄可能是其中的关键因素之一。目的:对近年来骨关节炎中的临床现表现特点及沉默信息调节因子1在骨关节炎发生发展中的研究进展做一概述。方法:计算机检索中国期刊全文数据库、Pub Med、Springer Link、Elsevier Science Direct数据库,检索时间1987年1月至2016年1月,检索词分别为"骨关节炎;沉默信息调节因子1;软骨"和"Osteoarthritis,Cartilage,Silent information regulation 1"。对纳入符合标准的83条文献进行分析。结果与结论:研究表明,在多种信号通路中去乙酰化修饰调控大量细胞因子的表达和生物学功能,继而影响骨关节炎的发生和发展。沉默信息调节因子1具有调节机体代谢,抑制细胞凋亡,修复DNA损伤,延缓衰老,抵抗应激反应等重要作用,同时在表观遗传学修饰、基因沉默和信号转导调节中发挥着重要的生物学功能,因此沉默信息调节因子1与各种年龄相关的疾病有关,如骨关节炎、骨质疏松症、糖尿病和阿尔茨海默症等。沉默信息调节因子1有望成为开发治疗骨关节炎药物的重要靶点,甚至可能在骨关节炎不成熟的阶段,逆转机械应力导致的软骨功能损伤。

BACKGROUND：Functional changes of some functional genes have been showed to trigger osteoarthritis, among which, age may be a critical one. OBJECTIVE：To summarize the clinical manifestations of osteoarthritis and the research process of silent information regulation 1 in the occurrence and development of osteoarthritis. METHODS：A computer-based retrieval was performed in the databases of CNKI, PubMed, SpringerLink, and Elsevier Science Direct using the keywords of＂osteoarthritis, silent information regulation 1 and cartilage＂in Chinese and English, respectively. Finally 83 eligible literatures were enrolled for analysis. RESULTS AND CONCLUSION：Deacetylation modification acts on the occurrence and development of osteoarthritis by regulating the expression and biological function of various cytokines. Silent information regulation 1 cannot only regulate body metabolism, inhibit cell apoptosis, repair DNA injury, delay senescence and resist to stress, but also play important roles in the epigenetic modification, gene silencing and signal transduction. Therefore, silent information regulation 1 is involved in the age-related diseases, such as osteoarthritis, osteoporosis, diabetes and Alzheimer＆#39;s disease. Furthermore, silent information regulation 1 is likely to be an important target of osteoarthritis drugs, and even reverses mechanical stress-induced cartilage injury in the early stage of osteoarthritis.