肿瘤放化疗患者口服纽特舒玛乳清蛋白的营养评估

Nutritional evaluation of oral administration of NS whey protein in patients with tumor radiotherapy and chemotherapy

目的探讨可疑或中度营养不良的肿瘤放化疗患者口服纽特舒玛(NS)乳清蛋白的营养状况改善的有效性和安全性。方法纳入本研究病例共162例,设立对照组和NS组(NS乳清蛋白试验组)。NS组除一日三餐正常饮食外,口服NS乳清蛋白38.5 g(1勺)/次(约含乳清蛋白16.2 g),1日2次,连续服用15 d。比较两组Alb、Hb、营养状况、副作用情况。结果未经营养干预的对照组患者(Ctr组,16例),放、化疗治疗后第15天,Alb和Hb均下降,且差异有统计学意义(P<0.05);而经NS乳清蛋白营养干预组患者(NS组,146例),放、化疗治疗后第15天,Alb和Hb均有回升,且具有显著性差异(P<0.01);统计结果显示,NS组患者营养状况改善率达96.58%,其中显著改善达8.90%;副作用改善率达98.63%,其中显著改善达16.44%。结论 NS乳清蛋白能改善肿瘤放、化疗患者营养状况并改善放、化疗副反应。

Objective To investigate the nutritional status improvement efficacy and safety of oral administratioh of NS whey protein in tumor radiotherapy and chemotherapy patients with suspicious Or moderate malnutrition. Methods A total of 162 cases were included in this study. The control group and the WP group （whey protein test group） were established, by the method of multi-center trial and random enrollment. The experimental group was given oral whey protein 38.5 g （1 spoon）/time （about whey protein 16.2 g）, 2 times a day for 15 days, in addition to daily diet with three meals a day. The Alb, Hb, nutritional status and side effects between the two groups were compared. Results The levels of Alb and Hb were decreased at the 15th day after radiotherapy and chemotherapy in the control group （Ctr group, 16 cases） without nutritional intervention, and the differenCe was statistically significant（P〈0.05）. While the Alb and Hb,both rebounded at the 15th day after radiotherapy and chemotherapy in the NS whey protein nutrition intervention group （NS group, 146 cases）, and there were significant differences between the two groups （P〈0.01）. Responsible physician experience evaluation resuits showed that nutritional status Improvement rate of the patients in the NS group was 96.58%, of which there was 8.90% of significantly improvemerit. And the improvement rate of side effects was 98.63% in the NS group, of which the significantly improvement was： 16.44%. Conclusion NS whey protein can improve the nutritional status of cancer patients with radiotherapy and chemotherapy and improve the side effects of radiotherapy and chemotherapy.