强直性脊柱炎动物模型归类及其机制研究与进展

Research progress of classification and pathogenesis in ankylosing spondylitis animal models

背景:强直性脊柱炎是以侵犯中轴关节为主的慢性炎症自身免疫性疾病,目前发病机制仍不明确。需要进行深入的研究,稳定和成熟的动物模型显得更加重要。强直性脊柱炎脊柱和骶髂生物样本非常的稀缺,然而学者们对该病发病机制的理解很大程度上依赖于强直性脊柱炎动物模型的研究成果,目前的几种强直性脊柱炎动物模型均无法很好的代表强直性脊柱炎的病理病程。目的:通过总结以往各类强直性脊柱炎动物模型临床和病理特征,为进一步完善此类动物模型提供基础。方法:以("Ankylosing Spondylitis"AND"Animal Models")OR("HLA-B27"AND"Animal models")为英文检索词,以("强直性脊柱炎"AND"动物模型"OR("人类白细胞抗原B27"AND"动物模型")为中文检索词,通过检索Pub Med/CNKI数据库,排除临床新药研究、动物模型仅为研究手段及未涉及动物模型机制探讨的文章。对目前常见的强直性脊柱炎动物模型发病机制、病理特征进行归纳总结。结果与结论:纳入综述的文章为37篇。把目前现有的几种强直性脊柱炎动物模型归为3大类,各类动物模型各有其优缺点,它们均能模拟强直性脊柱炎的某些发病特征,但是仍缺乏强直性脊柱炎最具代表性的动物模型,考虑到强直性脊柱炎的发病与肠道菌群密切相关,并将各类动物模型的发病特与之结合,有望复制出更加稳定和完善的强直性脊柱炎动物模型。

BACKGROUND： Ankylosing spondylitis is a chronic inflammatory antoimmune disease involving the axial skeletion. So far, the pathogenesis of the disease is not clear. It still needs to build a more mature and stable animal model to promote further research. Since human tissue specimens of the spine and sacroiliac joint are very difficult to obtain, research has been hinders by limits availability of tissue samples from patients. The understanding of ankylosing spondylitis pathogenesis greatly depends on ankylosing spondylitis animal models. Howerer, the several animal models we have today cannot very good represent ankylosing spondylitis pathogenesis and disease progress.OBJECTIVE： To summarize clinical and pathological characteristics of animal models of ankylosing spondylitis to further provide the basis for further improvement of this animal model.METHODS： The databases of PubMed/CNKI were retrieved with key words of ＂Ankylosing Spondylitis, Animal Models,HLA-B27＂. We excluded clinical research of new drugs and studies in animal models for the research methods or studies that did not mention the mechanism of animal models. Pathogenesis and pathological characteristics of animal models of ankylosing spondylitis were summarized.RESULTS AND CONCLUSION： This review included 37 studies and summarized three kinds of animal models of ankylosing spondylitis. All kinds of animal models have their own characteristics and disadvantages. They can simulate some features of ankylosing spondylitis. But to some extent, there is still lack of animal models of representing ankylosing spondylitis. The incidence of ankylosing spondylitis is closely related to the intestinal flora. The combination of different types of animal models is possible to reproduce more stable and perfect animal model of ankylosing spondylitis.