体内腰椎间盘退变动物模型的研究与进展

Recent advances in vivo model of lumbar disc degeneration

背景:良好的腰椎间盘退变动物模型的建立,可以生动直观的帮助医疗工作者理解腰椎间盘退行性改变的病理生理变化以及疾病的发生发展规律,并可以通过成熟的退变模型,探索研究更有效的治疗方式。目的:综述近年国内外体内腰椎间盘退变动物模型的研究进展。方法:第一作者应用计算机检索至2016年5月为止的Pub Med数据库、中国期刊全文数据库相关文章,英文检索词"lumbar disc,degeneration,animal model,vivo model";中文检索词"腰椎间盘,退行性病变,动物模型,在体模型"。共检索到161篇相关文献,49篇文献符合纳入标准。结果与结论:(1)建立一种直观可靠的椎间盘退变动物模型将助力腰椎间盘退变疾病的各项基础研究,并为腰椎间盘退变的修复治疗提供良好的实验载体;(2)经过80余年的发展,腰椎间盘退变的动物模型已形成了物种多、方法全、思路新的制作模式。现行制作模型各具优势,不可替代,但还存在可控性不强,安全度不高或观察周期长等问题,这些都需要进一步研究探索。

BACKGROUND： Establishment of lumbar disc degeneration in animal models can help doctors understand the development rules and pathophysiological changes of this disease, and can explore and research more rational treatment by creating animal models.OBJECTIVE： To review recent advances in vivo model of lumbar disc degeneration.METHODS： The first author used the computer to search related articles on PubMed database and Chinese Journal Full-text Database from inception to May 2016. The search key words were ＂lumbar disc, degeneration, animal model,vivo model＂. A total of 161 related articles were retrieved and 49 of them met the inclusion criteria.RESULTS AND CONCLUSION： （1） Building an intuitive and reliable animal model of lumbar disc degeneration will not only help the basic research of degenerative disc disease, but also provide a good experimental carrier for the repair treatment of degenerative lumbar disc. （2） After more than 80 years of development, the animal model of lumbar disc degeneration has formed a production mode of ＂more species, more methods and newer ideas＂. Current models have their own advantages, cannot be replaced. However, problems such as poor controllability, low degree of safety or long observation period are still exiting more or less. All these need further research and exploration.