pH值法唾液尿素酶试验检测幽门螺杆菌研究

Study on Detection of Helicobacter Pylori by pH Value Method

目的:探讨p H值法唾液快速尿素酶试验(SRUT)检测幽门螺杆菌(Hp)的价值。方法:对1600例患者,用SRUT和^(14)C-尿素呼气试验(^(14)C-UBT)检测Hp,统计两种试验检测的结果,以^(14)C-UBT为金标准,用贝叶斯定理方法对SRUT进行评价。检测结果的变异系数应≤10%。结果:在1600例受检者中SRUT阳性标本733例,阳性率为45.81%;^(14)C-UBT阳性标本678例,阳性率为42.38%。SRUT灵敏性为97.79%,特异性为92.41%,阳性预测值为90.45%,阴性预测值为98.27%,准确性为94.69%,差异性为5.31%,变异系数低于10%。结论:SRUT与^(14)C-UBT在Hp的检测方面具有相同的应用价值,SRUT快捷、安全、简便、价廉,是一种检测Hp的新方法。

Objective： To study the value of saliva urease test （ SRUT ） with pH method in the detection of Helicobacter pylori （ Hp ） .Method： SRUT and 14C-urea breath test （ 14C-UBT ） were used to detect Hp in 1600 patients, the results of two kinds of test were analyzed, and 14C-UBT was used as the gold standard, the method was used to evaluate SRU.The coefficient of variation of test results should was less than or equal to 10%.Result： In 1600 cases, the positive 733 cases of the SRUT, the positive rate was 45.81%; the positive 678 cases Of the 14C-UBT, the positive rate was 42.38%.The SRUT sensitivity was 97.79%, specificity was 92.41%, positive predictive value was 90.45% and negative predictive value was 98.27%, the accuracy was 94.69%, the difference was 5.31%, the variation coefficient was less than 10%.Conclusion： SRUT and 14C-UBT in the detection of Hp has the same application value, SRUT is fast, safe, simple, cheap, is a new method to detect Hp.